解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
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儿科学
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生理学
基本医疗保健
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热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Data from the imaging literature have led to suggestions that permanent structural brain changes may be associated with bipolar disorder. Individuals diagnosed with bipolar disorder display deficits on a range of neuropsychological tasks in both the acute and euthymic phases of illness, and correlations between experi...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-5618.2005.00203.x
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:To report a case report of a geriatric patient with a 5-year history of gabapentin use for enhanced bipolar control, who was tapered off of gabapentin over 1 week. The patient displayed unique withdrawal symptoms after the taper of gabapentin. METHODS:The patient is an 81-year-old white female with a life-lo...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00200.x
更新日期:2005-06-01 00:00:00
abstract::Research into postnatal mood disorders to date has concentrated on depressive syndromes of varying severity and full-blown acute puerperal mania. However, clinical experience, backed up by a review of the literature, indicates that milder hypomanic symptoms also occur in the early puerperium. Although these symptoms m...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-5618.2005.00185.x
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVES:To compare the quality of life (QOL) of patients having dual diagnosis of bipolar affective disorder and substance dependence with those having either diagnosis alone and with healthy controls. METHODS:Cross-sectional assessment of the four groups of subjects was made. Euthymic bipolar patients and those su...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2004.00173.x
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVES:The mood-stabilizing drug valproic acid (VPA) exerts a neurotrophic effect on the human neuroblastoma cell line, SH-SY5Y. We aimed to establish whether other mood-stabilizing drugs have a similar action and which signalling pathways mediate this process. METHODS:We analysed the effects of the mood stabilize...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2004.00164.x
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:To examine the nature of executive deficits in euthymic patients with bipolar disorder (BD). METHODS:Fifteen euthymic BD patients and 13 controls were administered a battery of executive tasks including verbal fluency, Stroop, Theory of Mind (ToM) tests and selected subtests from the Cambridge Neuropsycholo...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2005.00254.x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:As part of a cost-effectiveness analysis for Department of Veterans Affairs Cooperative Studies Program #430, 'Reducing the Efficacy-Effectiveness Gap in Bipolar Disorder,' we conducted a time and motion study to quantify the time psychiatric clinical nurse specialist (CNS) care managers spent providing care...
journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1399-5618.2004.00159.x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:Several lines of evidence suggest that deficits in cognition persist in bipolar patients during periods of euthymia. Working memory impairment has been observed in euthymic bipolar patients and noted to be a significant source of functional deficits in psychiatric disorders. Functional changes associated wit...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2004.00117.x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To determine the impact of acute depression on quality of life (QOL) in patients with bipolar I disorder and to compare these results with published data on QOL in patients with unipolar depression. METHODS:Quality of life was assessed using the SF-36 in bipolar patients (n = 958) who had recently experience...
journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1399-5618.2004.00134.x
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:Patients with remitted bipolar disorder (BD) have persistent impairments in neuropsychological function, particularly in the domains of executive control and declarative memory [Br J Psychiatry 180 (2002) 293]. If these were the phenotypic expression of genetic vulnerability to BD, then healthy subjects with ...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2004.00122.x
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:Evaluate the efficacy and tolerability of quetiapine (QTP) combined with lithium (Li) or divalproex (DVP) in the treatment of acute mania. METHODS:Patients were randomized to 21 days of double-blind treatment with QTP plus Li/DVP, or placebo (PBO) plus Li/DVP. QTP was rapidly dosed up to a maximum of 800 mg/...
journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1399-5618.2004.00115.x
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:To investigate whether first admission with mania is associated with the occurrence of death in the family or with major stressful life events and to explore whether the associations change with age. METHODS:Case register study with linkage of the Danish Psychiatric Central Research Register, including data...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1111/j.1399-5618.2004.00102.x
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVES:Few studies have examined the abnormalities that underlie the neuroanatomy of bipolar disorder in youth. The aim of this study was to evaluate brain regions that are thought to modulate mood utilizing quantitative analyses of thin-slice magnetic resonance imaging (MRI) scans of adolescents with bipolar disor...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1046/j.1399-5618.2003.00087.x
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVES:Manic patients exhibit impaired verbal learning and memory, particularly following longstanding illness. However, it is unclear whether recognition and recall performance are differentially influenced by a manic mood state. METHODS:To examine this issue, we administered the California Verbal Learning Test a...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.2003.00055.x
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:Outcomes research in bipolar disorders, because of complex clinical variation over-time, offers demanding research design and statistical challenges. Longitudinal studies involving relatively large samples, with outcome measures obtained repeatedly over-time, are required. In this report, statistical methods...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2003.00033.x
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:We conducted a study of clinical presentation and family history in patients responsive to either of two commonly used mood stabilizers, lithium and lamotrigine. METHODS:The sample included 164 subjects from 21 families of bipolar probands, 14 responders to lithium and seven to lamotrigine. Diagnostic inform...
journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章
doi:10.1034/j.1399-5618.2003.00026.x
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:Bipolar disorder is associated with a high frequency of both completed suicides and suicide attempts. The primary aim of this study was to identify clinical predictors of suicide attempts in subjects with bipolar disorder. METHODS:We studied 336 subjects with a diagnosis of bipolar I, bipolar II, or schizoaf...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.2003.00017.x
更新日期:2003-02-01 00:00:00
abstract::Bipolar disorder is a complex condition that includes symptoms of mania, depression, and often anxiety. Diagnosing and treating bipolar depression is challenging, with the disorder often being diagnosed as unipolar depression. In addition, comorbid anxiety can be a significant detractor to successful outcomes, increas...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1111/j.1399-2406.2003.00061.x
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:This study examined health care resource utilization and direct health care costs among patients diagnosed with bipolar I disorder in a privately insured population. METHODS:Health care claims data for 2883 patients with a primary diagnosis of bipolar disorder were compared over a 1-year period (1997) with c...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.2002.01148.x
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:The purpose of the present study has been to examine differences in the laterality of pain in patients with migraine and comorbid unipolar depressive (UP) and bipolar II (BP II) disorders. METHODS:Semi-structured interviews of 102 patients with major affective disorders were conducted, using DSM-IV criteria...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.2002.01226.x
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:Significant debate exists on whether early onset bipolar disorder is mistakenly attributed to attention deficit hyperactivity disorder (ADHD) or conduct disorder (CD), or whether ADHD and CD are frequently misdiagnosed as mania. We review the literature on the extent to which these disorders can be reliably ...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2002.01191.x
更新日期:2002-08-01 00:00:00
abstract::Lithium, the major drug used to treat manic depressive illness, robustly protects cultured rat brain neurons from glutamate excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptors. The lithium neuroprotection against glutamate excitotoxiciy is long-lasting, requires long-term pretreatment and occurs at therap...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2002.01179.x
更新日期:2002-04-01 00:00:00
abstract::Inositol metabolism is well characterized in yeast at a molecular level, and yeast is the only eukaryote in which genetic, molecular and functional genomic approaches to identify lithium. valproate and inositol targets may be combined readily. It has been shown that lithium inhibits yeast inositol monophosphatase (enc...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.4.s1.2.x
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:Population isolates offer several advantages for those hoping to identify predisposition genes for bipolar disorder (BP). In this review article, the rationale for performing gene mapping studies in this type of population and the results of genetic mapping studies performed to date in population isolates ar...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2001.30605.x
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Topiramate, a newer antiepileptic agent, may benefit several neurological and psychiatric states, including bipolar disorder. CASE REPORT:A physically healthy, stockily built, 47-year-old, hypomanic Asian male with a >20-year history of uneventful use of psychotropic agents received topiramate in a dose tha...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Data from several studies suggest that medications, such as ketoconazole, which lower cortisol levels, may be effective for major depressive disorder (MDD). As with MDD, the manic, depressive, and mixed phases of bipolar disorder are frequently associated with elevated cortisol levels. The literature on the ...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2001.030103.x
更新日期:2001-02-01 00:00:00
abstract::It has become increasingly appreciated that the long-term treatment of complex neuropsychiatric disorders like bipolar disorder (BD) involves the strategic regulation of signaling pathways and gene expression in critical neuronal circuits. Accumulating evidence from our laboratories and others has identified the famil...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2000.20303.x
更新日期:2000-09-01 00:00:00
abstract::Calcium channel antagonists (CCAs) have many clinical applications, including their possible use in the treatment of bipolar disorder. Two justifications for this last application are some overlap in physiological activities of CCAs with those of lithium, and a possible association between bipolar disorder and calcium...
journal_title:Bipolar disorders
pub_type: 杂志文章,评审
doi:10.1034/j.1399-5618.2000.020204.x
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:Inositol is a constituent of the intracellular phosphatidyl inositol (PI) second messenger system, which is linked to various neurotransmitter receptors. Inositol crosses the blood-brain barrier in pharmacological doses, and has shown efficacy in a small double-blind study of unipolar depression. This pilot s...
journal_title:Bipolar disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1399-5618.2000.020107.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To review research findings on clinical effects of discontinuing lithium maintenance treatment. METHODS:Data from studies reported since 1970 plus our recent findings were updated. RESULTS:Discontinuing lithium maintenance treatment led to marked increases of early affective morbidity and suicidal risk. Gra...
journal_title:Bipolar disorders
pub_type: 杂志文章
doi:10.1034/j.1399-5618.1999.10106.x
更新日期:1999-09-01 00:00:00